Publications

April 2024

A scan-specific quality control acquisition for clinical whole-body (WB) MRI protocols

Sam Keaveney, Georgina Hopkinson, Julia E Markus, Andrew N Priest, Erica Scurr, Julie Hughes, Scott Robertson, Simon J Doran, David J Collins, Christina Messiou, Dow-Mu Koh and Jessica M Winfield. Physics in Medicine & Biology. https://doi.org/10.1088/1361-6560/ad4195

March 2024

Clinical [18F]FSPG Positron Emission Tomography Imaging Reveals Heterogeneity in Tumor-Associated System xc− Activity

Amy R. Sharkey, Norman Koglin, Erik S. Mittra, Sangwon Han, Gary J. R. Cook and Timothy H. Witney. Cancers 2024, 16(7), 1437.

Multicentre validation of CT grey-level co-occurrence matrix features for overall survival in primary oesophageal adenocarcinoma

Robert O’Shea, Samuel J. Withey, Kasia Owczarczyk, Christopher Rookyard, James Gossage, Edmund Godfrey, Craig Jobling, Simon L. Parsons, Richard J. E. Skipworth & Vicky Goh on behalf of the OCCAMS Consortium. European Radiology https://doi.org/10.1007/s00330-024-10666-y

February 2024

Sequential deep learning image enhancement models improve diagnostic confidence, lesion detectability, and image reconstruction time in PET

Meghi Dedja, Abolfazl Mehranian, Kevin M. Bradley, Matthew D. Walker, Patrick A. Fielding, Scott D. Wollenweber, Robert Johnsen & Daniel R. McGowan. EJNMMI Physics volume 11, Article number: 28 (2024)

Predicting programmed death-ligand 1 (PD-L1) expression with fluorine-18 fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters in resectable non-small cell lung cancer

Daniel Johnathan Hughes, Eleni Josephides, Robert O’Shea, Thubeena Manickavasagar, Carolyn Horst, Sarah Hunter, Philippe Tanière, Daisuke Nonaka, Mieke Van Hemelrijck, James Spicer, Vicky Goh, Andrea Bille, Eleni Karapanagiotou & Gary J. R. Cook. European Radiology https://doi.org/10.1007/s00330-024-10651-5.

Machine learning and radiomics for segmentation and classification of adnexal masses on ultrasound

Jennifer F. Barcroft, Kristofer Linton-Reid, Chiara Landolfo, Maya Al-Memar, Nina Parker, Chris Kyriacou, Maria Munaretto, Martina Fantauzzi, Nina Cooper, Joseph Yazbek, Nishat Bharwani, Sa Ra Lee, Ju Hee Kim, Dirk Timmerman, Joram Posma, Luca Savelli, Srdjan Saso, Eric O. Aboagye & Tom Bourne. npj Precision Oncology volume 8, Article number: 41 (2024).

Curation of myeloma observational study MALIMAR using XNAT: solving the challenges posed by real-world data

Simon J Doran, Theo Barfoot, Linda Wedlake, Jessica M Winfield, James Petts, Ben Glocker, Xingfeng Li, Martin Leach, Martin Kaiser, Tara D Barwick, Aristeidis Chaidos, Laura Satchwell, Neil Soneji, Khalil Elgendy, Alexander Sheeka, Kathryn Wallitt, Dow-Mu Koh, Christina Messiou, Andrea Rockall. Insights Imaging. 2024 Feb 16;15(1):47. doi: 10.1186/s13244-023-01591-7.

Deep representation learning of tissue metabolome and computed tomography annotates NSCLC classification and prognosis

Marc Boubnovski Martell, Kristofer Linton-Reid, Sumeet Hindocha, Mitchell Chen, Paula Moreno, Marina Álvarez‐Benito, Ángel Salvatierra, Richard Lee, Joram M. Posma, Marco A. Calzado & Eric O. Aboagye. npj Precision Oncology volume 8, Article number: 28 (2024)

December 2023

Bench to Bedside Development of [18F]Fluoromethyl-(1,2-2H4)choline ([18F]D4-FCH)

Amarnath Challapalli, Tara D. Barwick, Suraiya R. Dubash, Marianna Inglese, Matthew Grech-Sollars, Kasia Kozlowski, Henry Tam, Neva H. Patel, Mathias Winkler, Penny Flohr, Azeem Saleem, Amit Bahl, Alison Falconer, Johann S. De Bono, Eric O. Aboagye and Stephen Mangar. Molecules 2023, 28(24), 8018.

Deep learning-based segmentation of multisite disease in ovarian cancer

Thomas Buddenkotte, Leonardo Rundo, Ramona Woitek, Lorena Escudero Sanchez, Lucian Beer, Mireia Crispin‑Ortuzar, Christian Etmann, Subhadip Mukherjee, Vlad Bura, Cathal McCague, Hilal Sahin, Roxana Pintican, Marta Zerunian, Iris Allajbeu, Naveena Singh, Anju Sahdev, Laura Havrilesky, David E. Cohn, Nicholas W. Bateman, Thomas P. Conrads, Kathleen M. Darcy, G. Larry Maxwell, John B. Freymann, Ozan Öktem, James D. Brenton, Evis Sala and Carola‑Bibiane Schönlieb. European Radiology Experimental (2023) 7:77.

November 2023

Independent component analysis (ICA) applied to dynamic oxygen-enhanced MRI (OE-MRI) for robust functional lung imaging at 3 T

Sarah H Needleman, Mina Kim, Jamie R McClelland, Josephine H Naish, Marta Tibiletti, James P B O’Connor, Geoff J M Parker. Magn Reson Med. 2024 Mar;91(3):955-971.

Feasibility of dynamic T2 *-based oxygen-enhanced lung MRI at 3T

Mina Kim, Josephine H. Naish, Sarah H. Needleman, Marta Tibiletti, Yohn Taylor, James P. B. O’Connor, Geoff J. M. Parker. Magn Reson Med. 2023; 1-15. doi: 10.1002/mrm.29914

Is System xc− a Suitable Target for Tumour Detection and Response Assessment with Imaging?

Amy R. Sharkey, Timothy H. Witney and Gary J. R. Cook. Cancers 2023, 15(23), 5573.

Weakly supervised segmentation models as explainable radiological classifiers for lung tumour detection on CT images

Robert O’Shea, Thubeena Manickavasagar, Carolyn Horst, Daniel Hughes, James Cusack, Sophia Tsoka, Gary Cook & Vicky Goh. Insights into Imaging volume 14, Article number: 195 (2023)

October 2023

Association of dynamic contrast-enhanced MRI and 18F-Fluorodeoxyglucose PET/CT parameters with neoadjuvant therapy response and survival in esophagogastric cancer

Samuel J. Withey, Kasia Owczarczyk, Mariusz T. Grzeda, Connie Yip, Harriet Deere, Mike Green, Nick Maisey, Andrew R. Davies, Gary J. Cook, Vicky Goh, Guy’s & St Thomas’ Esophagogastric Research Group. EJSO Volume 49, Issue 10, 106934.

Integrated radiogenomics models predict response to neoadjuvant chemotherapy in high grade serous ovarian cancer

Mireia Crispin-Ortuzar, Ramona Woitek, Marika A. V. Reinius, Elizabeth Moore, Lucian Beer, Vlad Bura, Leonardo Rundo, Cathal McCague, Stephan Ursprung, Lorena Escudero Sanchez, Paula Martin-Gonzalez, Florent Mouliere, Dineika Chandrananda, James Morris, Teodora Goranova, Anna M. Piskorz, Naveena Singh, Anju Sahdev, Roxana Pintican, Marta Zerunian, Nitzan Rosenfeld, Helen Addley, Mercedes Jimenez-Linan, Florian Markowetz, Evis Sala & James D. Brenton. Nature Communications volume 14, Article number: 6756 (2023).

Image quality in whole-body MRI using the MY-RADS protocol in a prospective multi-centre multiple myeloma study

Sam Keaveney, Alina Dragan, Mihaela Rata, Matthew Blackledge, Erica Scurr, Jessica M. Winfield, Joshua Shur, Dow-Mu Koh, Nuria Porta, Antonio Candito, Alexander King, Winston Rennie, Suchi Gaba, Priya Suresh, Paul Malcolm, Amy Davis, Anjumara Nilak, Aarti Shah, Sanjay Gandhi, Mauro Albrizio, Arnold Drury, Guy Pratt, Gordon Cook, Sadie Roberts, Matthew Jenner, Sarah Brown, Martin Kaiser & Christina Messiou. Insights into Imaging volume 14, Article number: 170 (2023).

August 2023
Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform

Zixuan Yangb, Chris Barnesb, Juozas Domarkasa, Joanna Koch-Paszkowskia, John Wrighta, Ala Amgheibb, Isaline Renard, Ruisi Fub, Stephen Archibald, Eric O. Aboagye and Louis Allott. React. Chem. Eng., 2023. DOI: 10.1039/D3RE00307H

Integrating Artificial Intelligence Tools in the Clinical Research Setting: The Ovarian Cancer Use Case

Lorena Escudero Sanchez, Thomas Buddenkotte, Mohammad Al Sa’d, Cathal McCague, James Darcy, Leonardo Rundo, Alex Samoshkin, Martin J. Graves, Victoria Hollamby, Paul Browne, Mireia Crispin-Ortuzar, Ramona Woitek, Evis Sala, Carola-Bibiane Schönlieb, Simon J. Doran and Ozan Öktem. Diagnostics 13, no. 17: 2813. https://doi.org/10.3390/diagnostics13172813

July 2023

A pipeline to further enhance quality, integrity and reusability of the NCCID clinical data

Anna Breger, Ian Selby, Michael Roberts, Judith Babar, Effrossyni Gkrania-Klotsas, Jacobus Preller, Lorena Escudero Sánchez, AIX-COVNET Collaboration, James H. F. Rudd, John A. D. Aston, Jonathan R. Weir-McCall, Evis Sala & Carola-Bibiane Schönlieb. Scientific Data volume 10, Article number: 493 (2023).

Feasibility of [18F]fluoropivalate hybrid PET/MRI for imaging lower and higher grade glioma: a prospective first-in-patient pilot study

Shahriar Islam, Marianna Inglese, Matthew Grech-Sollars, Preetha Aravind, Suraiya Dubash, Tara D. Barwick, Kevin O’Neill, James Wang, Azeem Saleem, James O’Callaghan, Giulio Anchini, Matthew Williams, Adam Waldman & Eric O. Aboagye. European Journal of Nuclear Medicine and Molecular Imaging (25 July 2023).

Diffusion-weighted imaging complements T2-weighted MRI for tumour response assessment in squamous anal carcinoma

Davide Prezzi, Keerthini Muthuswamy, Ashik Amlani, Kasia Owczarczyk, Ahmed Elowaidy, Tina Mistry, Paul Bassett & Vicky Goh. Eur Radiol (2023). https://doi.org/10.1007/s00330-023-09942-0

Evaluation of [18F]AlF-EMP-105 for Molecular Imaging of C-Met

Jin Hui Teh, Ala Amgheib, Ruisi Fu, Chris Barnes, Joel Abrahams, Ali Ashek, Ning Wang, Zixuan Yang, Muneera Mansoorudeen, Nicholas J. Long and Eric O. Aboagye. Pharmaceutics 2023, 15(7), 1915; https://doi.org/10.3390/pharmaceutics15071915

Independent component analysis (ICA) applied to dynamic oxygen-enhanced MRI (OE-MRI) for robust functional lung imaging at 3 T

Sarah H. Needleman, Mina Kim, Jamie R. McClelland, Josephine H. Naish, Marta Tibiletti, James P. B. O’Connor, Geoff J. M. Parker. bioRxiv 2023.07.05.547787.

June 2023

A Subset of Non-Small Cell Lung Cancer Patients Treated with Pemetrexed Show 18F-Fluorothymidine “Flare” on Positron Emission Tomography

Preetha Aravind, Sanjay Popat, Tara D. Barwick, Neil Soneji, Mark Lythgoe, Katherina B. Sreter, Jingky P. Lozano-Kuehne, Mattias Bergqvist, Neva Patel, Eric O. Aboagye and Laura M. Kenny. Cancers 2023, 15, 3718.

Using a Recurrent Neural Network To Inform the Use of Prostate-specific Antigen (PSA) and PSA Density for Dynamic Monitoring of the Risk of Prostate Cancer Progression on Active Surveillance

Nikita Sushentsev, Luis Abrego, Anna Colarieti, Nimalan Sanmugalingam, Arnaldo Stanzione, Jeries Paolo Zawaideh, Iztok Caglic, Alexey Zaikin, Oleg Blyuss, Tristan Barrett. European Urology Open Science Volume 52, June 2023, Pages 36-39.

May 2023

Inter-rater and intra-rater agreement of [99mTc]-labelled NM-01, a single-domain programmed death-ligand 1 (PD-L1) antibody, using quantitative SPECT/CT in non-small cell lung cancer

Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Damion Bailey, Kathryn Adamson, Vicky Goh, and Gary J. R. Cook. EJNMMI Res. 2023; 13: 51. Published online 2023 May 31. doi: 10.1186/s13550-023-01002-4

Open source code for the generation of digital reference objects for dynamic contrast-enhanced MRI analysis software validation

Andrew B. Gill, Ferdia A. Gallagher and Martin J. Graves. The British Journal of Radiology 2023 Vol. 96, No. 1147. Published Online 25 May 2023. https://doi.org/10.1259/bjr.20220976

Deep Representation Learning of Tissue Metabolome and Computed Tomography Images Annotates Non-invasive Classification and Prognosis Prediction of NSCLC

Marc Boubnovski Martell, Kristofer Linton-Reid, Sumeet Hindocha, Mitchell Chen, OCTAPUS-AI, Paula Moreno, Marina Álvarez-Benito, Ángel Salvatierra, Richard Lee, Joram M. Posma, Marco A Calzado, Eric O Aboagye. arXiv:2305.15590. https://arxiv.org/abs/2305.15590

Genitourinary Imaging in 2040

Vicky Goh. Radiology 2023 307:5.

Steps on the Path to Clinical Translation: A workshop by the British and Irish Chapter of the ISMRM

Penny L. Hubbard Cristinacce, Julia E. Markus, Shonit Punwani, Rebecca Mills, Maria Yanez Lopez, Matthew Grech-Sollars, Fabrizio Fasano, John C. Waterton, Michael J. Thrippleton, Matt G. Hall, James P. B. O’Connor, Susan T. Francis, Ben Statton, Kevin Murphy, Po-Wah So, Harpreet Hyare. Magn Reson Med. 24 May 2023;1-7. doi: 10.1002/mrm.29704.

April 2023

The Use of Machine Learning Models and Radiomics for Segmentation and Classification of Adnexal Masses on Ultrasound: A multi-cohort retrospective study

Jennifer F Barcroft, Kristofer Linton-Reid, Chiara Landolfo, Maya Al Memar, Nina Parker, Chris Kyriacou, Maria Munaretto, Martina Fantauzzi, Nina Cooper, Joseph Yazbek, Nishat Bharwani, Sa ra Lee, Ju Hee Kim, Dirk Timmerman, Joram M. Posma, Luca Savelli, Srdjan Saso, Eric O. Aboagye, Tom Bourne. medRxiv 2023.04.26.23289150; doi: https://doi.org/10.1101/2023.04.26.23289150

Dynamic oxygen-enhanced MRI of the lung at 3 T: feasibility, repeatability and reproducibility

Mina Kim, Josephine H. Naish, Sarah H. Needleman, Marta Tibiletti, Yohn Taylor, James P. B. O’Connor, Geoff J. M. Parker. bioRxiv 2023.04.09.536144; doi: https://doi.org/10.1101/2023.04.09.536144

Comparing biparametric to multiparametric MRI in the diagnosis of clinically significant prostate cancer in biopsy-naive men (PRIME): a prospective, international, multicentre, non-inferiority within-patient, diagnostic yield trial protocol

Aqua Asif, Arjun Nathan, Alexander Ng, Pramit Khetrapal, Vinson Wai-Shun Chan, Francesco Giganti, Clare Allen, Alex Freeman, Shonit Punwani, Paula Lorgelly, Caroline S Clarke, Chris Brew-Graves, Nicola Muirhead, Mark Emberton, Ridhi Agarwal, Yemisi Takwoingi, Jonathan J Deeks, Caroline M Moore, Veeru Kasivisvanathan, PRIME Trial Group. BMJ Open 2023;13:e070280.

March 2023

First-in-human technique translation of oxygen-enhanced MRI to an MR Linac system in patients with head and neck cancer

Michael J. Dubec, David L. Buckley, Michael Berks, Abigael Clough, John Gaffney, Anubhav Datta, Damien J. McHugh, Nuria Porta, Ross A. Little, Susan Cheung, Christina Hague, Cynthia L. Eccles, Peter J. Hoskin, Robert G. Bristow, Julian C. Matthews, Marcel van Herk, Ananya Choudhury, Geoff J.M. Parker, Andrew McPartlin, James P.B. O’Connor. Radiotherapy and Oncology Volume 183, June 2023, 109592.

Advanced Imaging for Detection of Foci of Infection in Staphylococcus aureus Bacteremia- Can a Scan Save Lives?

Anna L. Goodman, Alice Packham, Amy R. Sharkey, Gary J.R. Cook. Seminars in Nuclear Medicine
Volume 53, Issue 2, March 2023, Pages 175-183

Versatile Diphosphine Chelators for Radiolabeling Peptides with 99mTc and 64Cu

Ingebjørg N. Hungnes, Truc Thuy Pham, Charlotte Rivas, James A. Jarvis, Rachel E. Nuttall, Saul M. Cooper, Jennifer D. Young, Philip J. Blower, Paul G. Pringle, and Michelle T. Ma. Inorg. Chem. March 27, 2023.

February 2023

Amplified therapeutic targets in high-grade serous ovarian carcinoma – a review of the literature with quantitative appraisal

Thomas Talbot, Haonan Lu & Eric O. Aboagye. Cancer Gene Therapy February 20, 2023.

A Novel Radiogenomics Biomarker for Predicting Treatment Response and Pneumotoxicity from Programmed Cell Death-1 Pathway Inhibition in Non-Small Cell Lung Cancer

Mitchell Chen, Haonan Lu, Susan J. Copley, Yidong Han, Andrew Logan, Patrizia Viola, Alessio Cortellini, David J. Pinato, Danielle Power, Eric O. Aboagye. Journal of Thoracic Oncology February 09, 2023. DOI:https://doi.org/10.1016/j.jtho.2023.01.089

Lesion-specific 3D-printed moulds for image-guided tissue multi-sampling of ovarian tumours: A prospective pilot study

Maria Delgado-Ortet, Marika A. V. Reinius, Cathal McCague, Vlad Bura, Ramona Woitek, Leonardo Rundo, Andrew B. Gill, Marcel Gehrung, Stephan Ursprung, Helen Bolton, Krishnayan Haldar, Pubudu Pathiraja, James D. Brenton, Mireia Crispin-Ortuzar, Mercedes Jimenez-Linan, Lorena Escudero Sanchez and Evis Sala. Front. Oncol., 13 February 2023.

Time series radiomics for the prediction of prostate cancer progression in patients on active surveillance

Nikita Sushentsev, Leonardo Rundo, Luis Abrego, Zonglun Li, Tatiana Nazarenko, Anne Y. Warren, Vincent J. Gnanapragasam, Evis Sala, Alexey Zaikin, Tristan Barrett & Oleg Blyuss. Eur Radiol (2023). https://doi.org/10.1007/s00330-023-09438-x

January 2023

Deep learning-based Segmentation of Multi-site Disease in Ovarian Cancer

Thomas Buddenkotte, Leonardo Rundo, Ramona Woitek, Lorena Escudero Sanchez, Lucian Beer, Mireia Crispin-Ortuzar, Christian Etmann, Subhadip Mukherjee, Vlad Bura, Cathal McCague, Hilal Sahin, Roxana Pintican, Marta Zerunian, Iris Allajbeu, Naveena Singh, Sahdev Anju, Laura Havrilesky, David E. Cohn, Nicholas W. Bateman, Thomas P. Conrads, Kathleen M. Darcy, G. Larry Maxwell, John B. Freymann, Ozan Öktem, James D. Brenton, Evis Sala, and Carola-Bibiane Schönlieb. medRxiv, 11 Jan 2023. DOI: 10.1101/2023.01.10.22279679 

Advanced Imaging for Detection of Foci of Infection in Staphylococcus aureus Bacteremia- Can a Scan Save Lives?

Anna L. Goodman, Alice Packham, Amy R. Sharkey, Gary J.R. Cook. Seminars in Nuclear Medicine 22 January 2023. https://doi.org/10.1053/j.semnuclmed.2023.01.002

Radiotheranostics in oncology: Making precision medicine possible

Eric O. Aboagye, Tara D. Barwick, Uwe Haberkorn. CA Cancer J Clin. 2023; 1- 20. doi:10.3322/caac.21768

December 2022

Timing of hypoxia PET/CT imaging after 18F-fluoromisonidazole injection in non-small cell lung cancer patients

Pauline Bourigault, Michael Skwarski, Ruth E. Macpherson, Geoff S. Higgins, and Daniel R. McGowan. Sci Rep. 2022; 12: 21746.

November 2022

The role of [18F]fluorodopa positron emission tomography in grading of glioma

Joy R. Roach, Puneet Plaha, Daniel R. McGowan & Geoff S. Higgins. Journal of Neuro-Oncology 24 November 2022.

AI for Early Detection of Renal Cancer in Computed Tomography: A Review

William C. McGough, Lorena Escudero Sánchez, Cathal McCague, Grant D. Stewart, Carola-Bibiane Schönlieb, Evis Sala and Mireia Crispín-Ortuzar. Cambridge Prisms: Precision Medicine. Published online by Cambridge University Press: 11 November 2022.

Non-Small Cell Lung Cancer (NSCLC) in Young Adults, Age < 50, Is Associated with Late Stage at Presentation and a Very Poor Prognosis in Patients That Do Not Have a Targeted Therapy Option: A Real-World Study

Daniel Johnathan Hughes, Matthaios Kapiris, Andreja Podvez Nevajda, Harriet McGrath, Chara Stavraka, Shahreen Ahmad, Benjamin Taylor, Gary J. R. Cook, Sharmistha Ghosh, Debra Josephs, Elias Pintus, Spyridon Gennatas, Andrea Bille, Kimuli Ryanna, George Santis, Ana Montes, Mieke Van Hemelrijck, Eleni Karapanagiotou, Daniel Smith, James Spicer and Alexandros Georgiou. Cancers 2022, 14, 6056.

October 2022

Radiomic and Volumetric Measurements as Clinical Trial Endpoints—A Comprehensive Review

Ionut-Gabriel Funingana, Pubudu Piyatissa, Marika Reinius, Cathal McCague, Bristi Basu and Evis Sala. Cancers 2022, 14, 5076.

September 2022

Calibrating Ensembles for Scalable Uncertainty Quantification in Deep Learning-based Medical Segmentation

Thomas Buddenkotte, Lorena Escudero Sanchez, Mireia Crispin-Ortuzar, Ramona Woitek, Cathal McCague, James D. Brenton, Ozan Oktem, Evis Sala, and Leonardo Rundo. arXiv 20 September 2022.

Photoacoustic imaging radiomics in patient-derived xenografts: a study on feature sensitivity and model discrimination

Lorena Escudero Sanchez, Emma Brown, Leonardo Rundo, Stephan Ursprung, Evis Sala, Sarah E. Bohndiek & Ignacio Xavier Partarrieu. Scientific Reports volume 12, Article number: 15142 (07 September 2022).

Clinical translation of quantitative magnetic resonance imaging biomarkers – An overview and gap analysis of current practice

Penny L. Hubbard Cristinacce, Sam Keaveney, Eric O. Aboagye, Matt G. Hall, Ross A. Little, James P.B. O’Connor, Geoff J.M. Parker, John C. Waterton, Jessica M. Winfield, Maite Jauregui-Osoro. Physica Medica Volume 101, September 2022, Pages 165-182.

Weakly supervised Unet: an image classifier which learns to explain itself

Robert John O’Shea, Carolyn Horst, Thubeena Manickavasagar, Daniel Hughes, James Cusack, Sophia Tsoka, Gary Cook, Vicky Goh. bioRxiv 2022.09.09.507144; doi: https://doi.org/10.1101/2022.09.09.507144.

Feasibility and sensitivity study of radiomic features in photoacoustic imaging of patient-derived xenografts

Escudero Sanchez, L., Brown, E., Rundo, L., Ursprung, S., Sala, E., Bohndiek, S. E., & Partarrieu, I. X. Scientific Reports volume 12, Article number: 15142 (2022).

August 2022

Avoiding Unnecessary Biopsy after Multiparametric Prostate MRI with VERDICT Analysis: The INNOVATE Study

Saurabh Singh, Harriet Rogers, Baris Kanber, Joey Clemente, Hayley Pye, Edward W. Johnston, Tom Parry, Alistair Grey, Eoin Dinneen, Greg Shaw, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Francesco Giganti, David Atkinson, Caroline M. Moore, Hayley C. Whitaker, Daniel C. Alexander, Eleftheria Panagiotaki, Shonit Punwani. Radiology 2022 305:3, 623-630.

July 2022

Radiomic Signatures Associated with CD8+ Tumour-infiltrating Lymphocytes: A Systemic Review and Quality Assessment Study

Syafiq Ramlee, David Hulse, Kinga Bernatowicz,Raquel Pérez-López,Evis Sala and Luigi Aloj. Cancers 2022, 14(15), 3656; https://doi.org/10.3390/cancers14153656

Implementation of Whole‑Body MRI (MY‑RADS) within the OPTIMUM/MUKnine multi‑centre clinical trial for patients with myeloma

Mihaela Rata, Matthew Blackledge, Erica Scurr, Jessica Winfield, Dow‑Mu Koh, Alina Dragan, Antonio Candito, Alexander King, Winston Rennie, Suchi Gaba, Priya Suresh, Paul Malcolm, Amy Davis, Anjumara Nilak, Aarti Shah, Sanjay Gandhi, Mauro Albrizio, Arnold Drury, Sadie Roberts, Matthew Jenner, Sarah Brown, Martin Kaiser and Christina Messiou. Insights into Imaging (2022) 13:123.

Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-13C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study

Fulvio Zaccagna, Mary A. McLean, James T. Grist, Joshua Kaggie, Richard Mair, Frank Riemer, Ramona Woitek, Andrew B. Gill, Surrin Deen, Charlie J. Daniels, Stephan Ursprung, Rolf F. Schulte, Kieren Allinson, Anita Chhabra, Marie-Christine Laurent, Matthew Locke, Amy Frary, Sarah Hilborne, Ilse Patterson, Bruno D. Carmo, Rhys Slough, Ian Wilkinson, Bristi Basu, James Wason, Jonathan H. Gillard, Tomasz Matys, Colin Watts, Stephen J. Price, Thomas Santarius, Martin J. Graves, Sarah Jefferies, Kevin M. Brindle, Ferdia A. Gallagher. Radiology: Imaging Cancer 2022 4:4.

June 2022

Radiomic assessment of oesophageal adenocarcinoma: a critical review of 18F-FDG PET/CT, PET/MRI and CT

Robert J. O’Shea, Chris Rookyard, Sam Withey, Gary J. R. Cook, Sophia Tsoka & Vicky Goh. Insights into Imaging volume 13, Article number: 104 (2022).

Clinically Interpretable Radiomics-Based Prediction of Histopathologic Response to Neoadjuvant Chemotherapy in High-Grade Serous Ovarian Carcinoma

Leonardo Rundo, Lucian Beer, Lorena Escudero Sanchez, Mireia Crispin-Ortuzar, Marika Reinius, Cathal McCague, Hilal Sahin, Vlad Bura, Roxana Pintican, Marta Zerunian, Stephan Ursprung, Iris Allajbeu, Helen Addley, Paula Martin-Gonzalez, Thomas Buddenkotte, Naveena Singh, Anju Sahdev, Ionut-Gabriel Funingana, Mercedes Jimenez-Linan, Florian Markowetz, James D. Brenton, Evis Sala and Ramona Woitek. Front. Oncol., 16 June 2022.

Bringing time‑of‑flight quality to non‑TOF PET images

Tami Freeman. Physics World – Nuclear Medicine Research Update. 20 June 2022.

May 2022

Image quality in MY-RADS whole-body MRI protocols applied in a prospective multi-centre multiple myeloma study

Keaveney S, Dragan A, Rata M, Blackledge M, Scurr E, Winfield J, Koh DM, Porta N, Candito A, King A, Rennie W, Gaba S, Suresh P, Malcolm P, Davis A, Nilak A, Shah A, Gandhi S, Albrizio M, Drury A, Roberts S, Jenner M, Brown S, Kaiser M and Messiou C. Proceedings of the 30th Annual Meeting of ISMRM, London, UK. 2022.

Development of a scan-specific quality control acquisition for clinical whole-body MRI (WB-MRI) protocols

Keaveney S, Hopkinson G, Scurr E, Olaru MA, Collins D, Messiou C, Koh DM and Winfield J. Proceedings of the 30th Annual Meeting of ISMRM, London, UK. 2022.

E-Consent—a guide to maintain recruitment in clinical trials during the COVID-19 pandemic

Ricardo Almeida-Magana, Hanna Maroof, Jack Grierson, Rosie Clow, Eoin Dinneen, Tarek Al-Hammouri, Nicola Muirhead, Chris Brew-Graves, John Kelly & Greg Shaw. Trials volume 23, Article number: 388 (2022).

Deep learning-based time-of-flight (ToF) image enhancement of non-ToF PET scans

Abolfazl Mehranian, Scott D. Wollenweber, Matthew D. Walker, Kevin M. Bradley, Patrick A. Fielding, Martin Huellner, Fotis Kotasidis, Kuan-Hao Su, Robert Johnsen, Floris P. Jansen & Daniel R. McGowan. European Journal of Nuclear Medicine and Molecular Imaging 4 May 2022.

April 2022

Improved 3D tumour definition and quantification of uptake in simulated lung tumours using deep learning

Laura Dal Toso, Zacharias Chalampalakis , Irène Buvat, Claude Comtat, Gary Cook, Vicky Goh, Julia A Schnabel and Paul K Marsden. Phys. Med. Biol. 67 (2022) 095013.

March 2022

Comparative performance of fully-automated and semi-automated artificial intelligence methods for the detection of clinically significant prostate cancer on MRI: a systematic review

Nikita Sushentsev, Nadia Moreira Da Silva, Michael Yeung, Tristan Barrett, Evis Sala, Michael Roberts & Leonardo Rundo. Insights into Imaging 25 March 2022, Vol. 13, Article number: 59.

Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans

J. M. Vicencio, R. Evans, R. Green, Z. An, J. Deng, C. Treacy, R. Mustapha, J. Monypenny, C. Costoya, K. Lawler, K. Ng, K. De-Souza, O. Coban, V. Gomez, J. Clancy, S. H. Chen, A. Chalk, F. Wong, P. Gordon, C. Savage, C. Gomes, T. Pan, G. Alfano, L. Dolcetti, J. N. E. Chan, F. Flores-Borja, P. R. Barber, G. Weitsman, D. Sosnowska, E. Capone, S. Iacobelli, D. Hochhauser, J. A. Hartley, M. Parsons, J. N. Arnold, S. Ameer-Beg, S. A. Quezada, Y. Yarden, G. Sala & T. Ng. Cell Death & Disease volume 13, Article number: 274 (2022)

February 2022

Advancing imaging biomarker development and translation through the National Cancer Imaging Translational Accelerator (NCITA)

Martina McAteer, Geoff Higgins (2022). Research Outreach, 128. DOI: 10.32907/RO-128-2267290092

Integrating the OHIF Viewer into XNAT: Achievements, Challenges and Prospects for Quantitative Imaging Studies

Simon J. Doran, Mohammad Al Sa’d, James A. Petts, James Darcy, Kate Alpert, Woonchan Cho, Lorena Escudero Sanchez, Sachidanand Alle, Ahmed El Harouni, Brad Genereaux, Erik Ziegler, Gordon J. Harris, Eric O. Aboagye, Evis Sala, Dow-Mu Koh and Dan Marcus. Tomography 12 February 2022, 8(1), 497-512.

Correlation between whole skeleton dual energy CT calcium-subtracted attenuation and bone marrow infiltration in multiple myeloma

Renyang Gu, Ashik Amlani, Ulrike Haberland, Dan Hodson, Matthew Streetly, Michela Antonelli, Isabel Dregely, Vicky Goh, on behalf of the Myeloma Imaging Research Group at Guy’s and St Thomas’ Hospitals, London and King’s College London. European Journal of Radiology 16 February 2022. DOI: https://doi.org/10.1016/j.ejrad.2022.110223

January 2022

Choosing appropriate patient-reported outcome measures for prostate disease

Alexander Ng, Pramit Khetrapal, Chris Brew-Graves, Nicola Muirhead, Aqua Asif, Vinson Wai-Shun Chan, Arjun Nathan, Veeru Kasivisvanathan. BJUI Compass. 12 January 2022. https://doi.org/10.1002/bco2.136

Unified Focal loss: Generalising Dice and cross entropy-based losses to handle class imbalanced medical image segmentation

Michael Yeung, Evis Sala, Carola-Bibiane Schönlieb & Leonardo Rundo. Computerized Medical Imaging and Graphics, Volume 95, January 2022, 102026.

December 2021

Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients

Pauline Bourigault, Michael Skwarski, Ruth E. Macpherson, Geoff S. Higgins & Daniel R. McGowan. EJNMMI Research, Volume 11, 130 (2021).

Initial experience in staging primary oesophageal/gastro-oesophageal cancer with 18F-FDG PET/MRI

Amy R. Sharkey, Bert-ram Sah, Samuel J. Withey, Shaheel Bhuva, Radhouene Neji, Sami Jeljeli, Adrian Green, Gary J. R. Cook, Vicky Goh, C. R. Baker, F. Chang, S. Chicklore, M. Cominos, A. Coombes, A. R. Davies, S. George, B. Gill-barman, J. N. Dunn, J. A. Gossage, N. Griffin M. Hill, O. Hynes, C. Iezzi, A. Jacques, M. Kelly, U. Mahadeva, N. Maisey, R. Mcewan, J. Meenan, S. Ngan, K. Owczarczyk, A. Qureshi, A. Reyhani, M. Subesinghe, G. Tham, J. Waters, S. S. Zeki. European Journal of Hybrid Imaging volume 5, Article number: 23 (2021)

November 2021

Characterising 18F-fluciclovine uptake in breast cancer through the use of dynamic PET/CT imaging

N. P. Scott, E. J. Teoh, H. Flight, B. E. Jones, J. Niederer, L. Mustata, G. M. MacLean, P. G. Roy, D. D. Remoundos, C. Snell, C. Liu, F. V. Gleeson, A. L. Harris, S. R. Lord & D. R. McGowan. Br J Cancer 126, 598–605 (2022).

Impact of GAN-based lesion-focuesed medical image super-resolution on the robustness of radiomic features

de Farias E. C., di Noia C., Han C., Sala E., Castelli M., & Rundo L. Scientific Reports, 11 (1), 1 November 2021. DOI: 10.1038/s41598-021-00898-z

October 2021

Snapshot imprinting: rapid identification of cancer cell surface proteins and epitopes using molecularly imprinted polymers

Stanislav S. Piletsky, Elena Piletska, Marta Poblock, Salvador Macip, Donald J.L. Jones, Marta Braga, Thong H. Cao, Rajinder Singh, Alan C. Spivey, Eric O. Aboagye, Sergey A. Piletsky. Nano Today, 41, 101304. Published online 05 Oct 2021. DOI: 10.1016/j.nantod.2021.101304

Focus U-Net: A novel dual attention-gated CNN for polyp segmentation during colonoscopy

Michael Yeung, Evis Sala, Carola-Bibiane Schönlieb, Leonardo Rundo. Comput Biol Med. Vol. 137, October 2021, 104815.

September 2021

‘Delivering high quality clinical imaging research’

McAteer Martina. Association of Medical Research Charities (AMRC) Blog, 22 Sept. 2021.

Serial changes in tumour measurements and apparent diffusion coefficients in prostate cancer patients on active surveillance with and without histopathological progression

Nikita Sushentsev, Iztok Caglic, Leonardo Rundo, Vasily Kozlov, Evis Sala, Vincent J Gnanapragasam and Tristan Barrett. Br J Radiol 2022; 95: 20210842.

A Low-Dose CT-Based Radiomic Model to Improve Characterization and Screening Recall Intervals of Indeterminate Prevalent Pulmonary Nodules

Leonardo Rundo, Roberta Eufrasia Ledda, Christian di Noia, Evis Sala, Giancarlo Mauri, Gianluca Milanese, Nicola Sverzellati,Giovanni Apolone, Maria Carla Gilardi, Maria Cristina Messa, Isabella Castiglioni and Ugo Pastorino. Diagnostics 2021, 11(9), 1610; September 2021 https://doi.org/10.3390/diagnostics11091610

3D deformable registration of longitudinal abdominopelvic CT images using unsupervised deep learning

Maureenvan Eijnatten, Leonardo Rundo, Joost Batenburg, Felix Lucka, Emma Beddowes, Carlos Caldas, Ferdia A. Gallagher, Evis Sala, Carola-Bibiane Schönlieb, Ramona Woitek. Computer Methods and Programs in Biomedicine Volume 208, September 2021, 106261.

July 2021

Image Enhancement of Whole-Body Oncology [18F]-FDG PET Scans Using Deep Neural Networks to Reduce Noise

Abolfazl Mehranian, Scott D. Wollenweber, Matthew D. Walker, Kevin M. Bradley, Patrick A. Fielding, Kuan-Hao Su, Robert Johnsen, Fotis Kotasidis, Floris P. Jansen & Daniel R. McGowan. Eur J Nucl Med Mol Imaging 49, 539–549 (2022).

Introduction to the National Cancer Imaging Translational Accelerator (NCITA): a UK-Wide Infrastructure for Multicentre Clinical Translation of Cancer Imaging Biomarkers

M. A. McAteer, J. P. B. O’Connor, D. M. Koh, H. Y. Leung, S. J. Doran, M. Jauregui-Osoro, N. Muirhead, C. Brew-Graves, E. R. Plummer, E. Sala, T. Ng, E. O. Aboagye, G. S. Higgins & S. Punwani. Br J Cancer 125, 1462–1465 (2021).

Integrated radiogenomics models predict response to neoadjuvant chemotherapy in high grade serous ovarian cancer

Mireia Crispin-Ortuzar, Ramona Woitek, Elizabeth Moore, Marika Reinius, Lucian Beer, Vlad Bura, Leonardo Rundo, Cathal McCague, Stephan Ursprung, Lorena Escudero Sanchez, Paula Martin-Gonzalez, Florent Mouliere, Dineika Chandrananda, James Morris, Teodora Goranova, Anna M. Piskorz, Naveena Singh, Anju Sahdev, Roxana Pintican, Marta Zerunian, Helen Addley, Mercedes Jimenez-Linan, Florian Markowetz, Evis Sala, James D. Brenton. MedRxiv 23 July 2021. doi.org/10.1101/2021.07.22.21260982

An Overview of Nuclear Medicine Research in the UK and the Landscape for Clinical Adoption

Jennifer D Young, Maite Jauregui-Osoro, Wai-Lup Wong, Margaret S Cooper, Gary Cook, Sally F Barrington, Michelle T Ma, Philip J Blower, Eric O Aboagye. Nuclear Medicine Communications 42(12):p 1301-1312, December 2021.

Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC

Ning Wang, Diana Brickute, Marta Braga, Chris Barnes, Haonan Lu, Louis Allott and Eric O. Aboagye. Pharmaceutics. 2021 Jul;13(7).

Effective Detection and Monitoring of Glioma Using [18F]FPIA PET Imaging

Vessela Vassileva, Marta Braga, Chris Barnes, Justyna Przystal, Ali Ashek, Louis Allott, Diana Brickute, Joel Abrahams, Keittisak Suwan, Angel M. Carcaboso, Amin Hajitou and Eric O. Aboagye. Biomedicines, 2021, 9, 811.

Artificial Intelligence Compared to Radiologists for the Initial Diagnosis of Prostate Cancer on Magnetic Resonance Imaging: A Systematic Review and Recommendations for Future Studies

Tom Syer, Pritesh Mehta, Michela Antonelli,Sue Mallett, David Atkinson, Sébastien Ourselin and Shonit Punwani. Cancers 2021, 13(13), 3318. 

June 2021

Reproducibility of CT-based radiomic features against image resampling and perturbations for tumour and healthy kidney in renal cancer patients

Margherita Mottola, Stephan Ursprung, Leonardo Rundo, Lorena Escudero Sanchez, Tobias Klatte, Iosif Mendichovszky, Grant D Stewart, Evis Sala & Alessandro Bevilacqua. Scientific Reports (2021) volume 11, Article number: 11542.

May 2021

“Real-world” radiomics from multi-vendor MRI: an original retrospective study on the prediction of nodal status and disease survival in breast cancer, as an exemplar to promote discussion of the wider issues

Simon J. Doran, Santosh Kumar, Matthew Orton, James d’Arcy, Fenna Kwaks, Elizabeth O’Flynn, Zaki Ahmed, Kate Downey, Mitch Dowsett, Nicholas Turner, Christina Messiou and Dow-Mu Koh.  Cancer Imaging (2021) 21:37.

A National Clinical Research MRI Quality Assurance and Quality Control Survey by NCITA

Penny L Hubbard Cristinacce, Damien J McHugh, Matthew R Orton, Arnold JV Benjamin, Ross A Little, James P. B. O’Connor, and Maite Jauregui-Osoro. Proc. Intl. Soc. Mag. Reson. Med. 29 (2021) 3819.

New PET technologies – embracing progress and pushing the limits

Nicolas Aide, Charline Lasnon, Adam Kesner, Craig S Levin, Irene Buvat, Andrei Iagaru, Ken Hermann, Ramsey D Badawi, Simon R Cherry, Kevin M Bradley, Daniel R McGowan. Eur J Nucl Med Mol Imaging (2021) 48:2711–2726

Combined 23Na and 13C imaging at 3.0 Tesla using a single-tuned large FOV birdcage coil

Joshua D. Kaggie, Titus Lanz, Mary A. McLean, Frank Riemer, Rolf F. Schulte, Arnold J. V. Benjamin, Dimitri A. Kessler, Chang Sun, Fiona J. Gilbert, Martin J. Graves, Ferdia A. Gallagher Magn Reson Med. Sept 2021. 86(3):1734-1745.

April 2021

Robustness of radiomic features in CT images with different slice thickness, comparing liver tumour and muscle

Lorena Escudero Sanchez, Leonardo Rundo, Andrew B. Gill, Matthew Hoare, Eva Mendes Serrao & Evis Sala. Scientific Reports (2021) volume 11, Article number: 8262.

UK Clinical Studies in Nuclear Medicine from 2015 to 2020: Examination of Data from Clinical Trial Repositories.

Jennifer D. Young; Maite Jauregui-Osoro; Michelle T. Ma; Philip J Blower. Nuclear Medicine Communications 2021, 42: 575–581, P31.

Overview of the QA/QC practices and quality management procedures at MR research institutions across the UK

Hubbard Cristinacce P. L., McHugh D. J., Little R. A., Orton M. R., Benjamin A. J. V., O’Connor J. P. B., and Jauregui-Osoro M. Quality Assurance in MRI IPEM Conferences 29 April 2021.

March 2021

Machine Learning for COVID-19 Diagnosis and Prognostication: Lessons for Amplifying the Signal While Reducing the Noise

Derek Driggs, Ian Selby, Michael Roberts, Effrossyni Gkrania-Klotsas, James H. F. Rudd, Guang Yang, Judith Babar, Evis Sala , Carola-Bibiane Schönlieb, on behalf of the AIX-COVNET collaboration Radiology: Artificial Intelligence, 2021 3:4

Jan 2021

Comparison of the diagnostic performance and impact on management of 18F-FDG PET/CT and whole-body MRI in multiple myeloma’ in the European Journal of Nuclear Medicine and Molecular Imaging. 

Olwen Westerland, Ashik Amlani, Christian Kelly-Morland, Michal Fraczek, Katherine Bailey, Mary Gleeson, Inas El-Najjar, Matthew Streetly, Paul Bassett, Gary J. R. Cook & Vicky Goh on behalf of the Myeloma Imaging Research Group at Guy’s & St Thomas’ Hospital, London and King’s College London. Eur J Nucl Med Mol Imaging 48, 2558–2565 (2021).

The emerging role of cell surface receptor and protein binding radiopharmaceuticals in cancer diagnostics and therapy

Aloj A, Attili A, Lau D, Caraco C, Lechermann L, Mendichovszky I, Harper I, Cheow H, Casey RT, Sala E, Gilbert FJ, Gallagher FA. Nuclear Medicine and Biology, Jan 2021. Vol 92: 53-64.

Image Contrast, Image Pre-Processing, and T1 Mapping Affect MRI Radiomic Feature Repeatability in Patients with Colorectal Cancer Liver Metastases

Damien J McHugh, Nuria Porta, Ross A Little, Susan Cheung, Yvonne Watson, Geoff J M Parker, Gordon C Jayson, James P B O’Connor.. Cancers (Basel) 2021 Jan 11;13(2):240.

Nov 2020

Test evaluation trials present different challenges for trial managers compared to intervention trials

Caroline Rick, Sue Mallett, James Brown, Ryan Ottridge, Andrew Palmer, Victoria Parker, Lee Priest, and Jonathan J. Deeks. Trials. 2020; 21: 987.

July 2020

Spatial heterogeneity of radiolabeled choline positron emission tomography in tumors of patients with non-small cell lung cancer: first-in-patient evaluation of [ 18 F]fluoromethyl-(1,2- 2 H 4)-choline

Suraiya Dubash, Marianna Inglese, Francesco Mauri, Kasia Kozlowski, Pritesh Trivedi, Mubarik Arshad , Amarnath Challapalli, Tara Barwick, Adil Al-Nahhas, Rex Stanbridge, Conrad Lewanski, Matthew Berry, Frances Bowen, Eric O Aboagye. Theranostics. 2020 Jul 9;10(19):8677-8690.

Hyperpolarized 13C-MRI of tumor metabolism demonstrates early metabolic response to neoadjuvant chemotherapy in breast cancer. Radiology: Imaging Cancer

Woitek R, McLean MA, Gill AB, Grist JT, Provenzano E, Patterson AJ, Ursprung S, Torheim T, Zaccagna F, Locke M, Laurent M-C, Hilborne S, Frary A, Beer L, Rundo L, Patterson I, Slough R, Kane J, Biggs H, Harrison E, Lanz T, Basu B, Baird R, Sala E, Graves MJ, Gilbert FJ, Abraham JE, Caldas C, Brindle KM, Gallagher FA., 2020. Radiology: Imaging Cancer 2020; 2(4): e200017. https://doi.org/10.1148/rycan.2020200017

Jan 2020

Radiomic features of cervical cancer on T2-and diffusion-weighted MRI: Prognostic value in low-volume tumors suitable for trachelectomy

Benjamin W. Wormald, Simon J. Doran, Thomas EJ. Ind,, James D’Arcy, James Petts, Nandita M. deSouza. Gynecologic Oncology 156 (2020): 107-114.

Diffusion model comparison identifies distinct tumor sub-regions and tracks treatment response

Damien J. McHugh, Grazyna Lipowska‐Bhalla, Muhammad Babur, Yvonne Watson, Isabel Peset, Hitesh B. Mistry, Penny L. Hubbard Cristinacce, Josephine H. Naish,  Jamie Honeychurch, Kaye J. Williams, James P. B. O’Connor,  and Geoffrey J. M. Parker. Magn Reson Med. 2020 Sep; 84(3): 1250–1263.