The NCITA CTU are delighted to have successfully activated study sites at Guy’s and St Thomas’ NHS Foundation Trust and the Imperial College London NHS Foundation Trust for the NCITA Exemplar 1 study (ClinicalTrials.gov: NCT04717674).
This is a phase 2, open-label study which will explore the relationship between short-chain fatty acid uptake and tumour proliferation in patients with solid tumours using [18F]FPIA PET/CT imaging.
The study will look at 21 patients with solid tumours due to undergo surgical resection in four NCITA accredited clinical research centres, which have different strengths in recruiting specific patient/tumour-type cohorts. The study sites include Guy’s and St Thomas’ NHS Foundation Trust, Imperial College London NHS Foundation Trust, The Royal Marsden Hospital and University College London Hospitals NHS Foundation Trust.
Short-chain fatty acid uptake in solid tumours will be assessed using the novel ([18F]FPIA) imaging radiotracer developed by Professor Eric Aboagye’s group at Imperial College London. Patients will have two scan visits (between 2-15 days apart) prior to any new treatment starting to check that the scan measurements are repeatable.
The NCITA exemplar study is led by Professor Tara Barwick (clinical chief investigator) and Professor Eric Aboagye (scientific chief investigator) at Imperial College London. The study is now open for recruitment.
For more details read our Exemplar 1 summary.