The NCITA Exemplar 1 FPIA Study is a multicentre feasibility study which is assessing the ability of [18F]-fluoropivalate (FPIA) PET/CT to determine short chain fatty acid uptake in solid tumours and tumour proliferation.

The study aims to recruit 21 patients with solid tumours due to undergo surgical resection in three NCITA accredited clinical research centres: Guy’s and St. Thomas’ NHS Foundation Trust, Imperial College Healthcare NHS Trust, and The Royal Marsden NHS Foundation Trust.  Each participant will be offered two research PET/CT scans, on two separate visits (between 2-15 days apart), prior to their surgery. Where two scans cannot be accommodated prior to the patient’s surgery date, a single scan will be performed. 

The FPIA study is currently open for recruitment ( NCT04717674) and to date 16 subjects have been recruited.  For more information see our NCITA patient resources webpage for the Exemplar 1 FPIA study.

This study, in combination with on-going brain and renal cancer studies at Imperial College, investigating the feasibility of 18F-FPIA for PET (doi: 10.3390/biomedicines9070811) and PET/MRI imaging of glioma (doi: 10.1007/s00259-023-06330-0) will provide the data required for a future large powered multicentre study to evaluate treatment outcomes using [18F]FPIA radiotracer.